{"id":2429,"date":"2026-01-15T04:08:25","date_gmt":"2026-01-15T04:08:25","guid":{"rendered":"https:\/\/pooja.plumead.com\/?p=2429"},"modified":"2026-01-15T04:08:59","modified_gmt":"2026-01-15T04:08:59","slug":"epigenetic-modulation-after-lasik-and-smile","status":"publish","type":"post","link":"https:\/\/pooja.plumead.com\/index.php\/2026\/01\/15\/epigenetic-modulation-after-lasik-and-smile\/","title":{"rendered":"Epigenetic Modulation After LASIK and SMILE"},"content":{"rendered":"<h2 data-start=\"298\" data-end=\"349\">\ud83d\udcc4 Epigenetic Modulation After LASIK and SMILE<\/h2>\n<p data-start=\"350\" data-end=\"439\"><strong data-start=\"350\" data-end=\"365\">Life | 2025<\/strong> <em data-start=\"366\" data-end=\"437\">(Epigenetic Modulation Directs Recovery Post LASIK and SMILE Surgery)<\/em><\/p>\n<p data-start=\"441\" data-end=\"849\">This experimental study explored how refractive surgeries such as <strong data-start=\"507\" data-end=\"516\">LASIK<\/strong> and <strong data-start=\"521\" data-end=\"530\">SMILE<\/strong> influence <strong data-start=\"541\" data-end=\"566\">epigenetic mechanisms<\/strong>\u2014specifically <strong data-start=\"580\" data-end=\"599\">DNA methylation<\/strong>\u2014in corneal tissue. While LASIK and SMILE are well-established techniques for correcting myopia, the molecular and chromatin-level responses that occur in the corneal stroma post-surgery are not fully understood.<\/p>\n<p data-start=\"851\" data-end=\"1277\">Researchers performed LASIK and SMILE procedures on donor eye globes and tracked changes in <strong data-start=\"943\" data-end=\"971\">DNA methylation patterns<\/strong> at different postoperative time points using comprehensive methylome profiling (Illumina Infinium HM850 array). They found <strong data-start=\"1095\" data-end=\"1137\">significant alterations in methylation<\/strong> across both procedures, suggesting that corneal wound healing involves dynamic epigenetic modulation.<\/p>\n<p data-start=\"1279\" data-end=\"1302\">Key findings include:<\/p>\n<ul data-start=\"1303\" data-end=\"2004\">\n<li data-start=\"1303\" data-end=\"1507\">\n<p data-start=\"1305\" data-end=\"1507\">Both LASIK and SMILE induced distinct <strong data-start=\"1343\" data-end=\"1371\">hypomethylation patterns<\/strong> in genes associated with <strong data-start=\"1397\" data-end=\"1424\">cytoskeletal activation<\/strong>, <strong data-start=\"1426\" data-end=\"1442\">inflammation<\/strong>, and <strong data-start=\"1448\" data-end=\"1466\">corneal repair<\/strong>.<\/p>\n<\/li>\n<li data-start=\"1508\" data-end=\"1770\">\n<p data-start=\"1510\" data-end=\"1770\">Specific genes\u2014such as <em data-start=\"1533\" data-end=\"1540\">smad3<\/em>, <em data-start=\"1542\" data-end=\"1549\">prkca<\/em>, <em data-start=\"1551\" data-end=\"1557\">ssh2<\/em>, and others involved in <strong data-start=\"1582\" data-end=\"1609\">sphingolipid metabolism<\/strong> and <strong data-start=\"1614\" data-end=\"1636\">mucin biosynthesis<\/strong>\u2014showed early changes post-surgery, indicating their potential roles in <strong data-start=\"1708\" data-end=\"1729\">tissue remodeling<\/strong>.<\/p>\n<\/li>\n<li data-start=\"1771\" data-end=\"2004\">\n<p data-start=\"1773\" data-end=\"2004\">These epigenetic changes may be linked to postoperative outcomes including <strong data-start=\"1848\" data-end=\"1876\">corneal haze development<\/strong>, and suggest new avenues for <strong data-start=\"1906\" data-end=\"1932\">therapeutic modulation<\/strong> using chromatin-targeting agents.<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"2006\" data-end=\"2396\"><strong data-start=\"2006\" data-end=\"2018\">Summary:<\/strong> This study reveals that LASIK and SMILE affect not only biomechanical and structural aspects of the cornea but also leave an <strong data-start=\"2144\" data-end=\"2168\">epigenetic footprint<\/strong> that may influence long-term healing and complications. Understanding these DNA methylation changes opens the door to potential <strong data-start=\"2297\" data-end=\"2327\">epigenetic-based therapies<\/strong> to optimize surgical outcomes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\ud83d\udcc4 Epigenetic Modulation After LASIK and SMILE Life | 2025 (Epigenetic Modulation Directs Recovery Post LASIK and SMILE Surgery) This experimental study explored how refractive surgeries such as LASIK and SMILE influence epigenetic mechanisms\u2014specifically DNA methylation\u2014in corneal tissue. While LASIK and SMILE are well-established techniques for correcting myopia, the molecular and chromatin-level responses that occur<\/p>\n","protected":false},"author":1,"featured_media":1485,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[16],"tags":[],"class_list":["post-2429","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"acf":[],"_links":{"self":[{"href":"https:\/\/pooja.plumead.com\/index.php\/wp-json\/wp\/v2\/posts\/2429","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pooja.plumead.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pooja.plumead.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pooja.plumead.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pooja.plumead.com\/index.php\/wp-json\/wp\/v2\/comments?post=2429"}],"version-history":[{"count":1,"href":"https:\/\/pooja.plumead.com\/index.php\/wp-json\/wp\/v2\/posts\/2429\/revisions"}],"predecessor-version":[{"id":2430,"href":"https:\/\/pooja.plumead.com\/index.php\/wp-json\/wp\/v2\/posts\/2429\/revisions\/2430"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pooja.plumead.com\/index.php\/wp-json\/wp\/v2\/media\/1485"}],"wp:attachment":[{"href":"https:\/\/pooja.plumead.com\/index.php\/wp-json\/wp\/v2\/media?parent=2429"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pooja.plumead.com\/index.php\/wp-json\/wp\/v2\/categories?post=2429"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pooja.plumead.com\/index.php\/wp-json\/wp\/v2\/tags?post=2429"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}